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CS-W001157 4
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1-(5-Aminopyridin-2-yl)ethan-1-one

  • CAS No. 51460-32-3

  • Cat. No. CS-0142552
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD10697714

*For research and further manufacturing use only, not for direct human use.

1-(5-Aminopyridin-2-yl)ethan-1-one|CS-0142552

Structure of 51460-32-3

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General Information

  • CAS No. 51460-32-3
  • Cat. No. CS-0142552
  • Purity ≥95%
  • MDL No. MFCD10697714
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O
  • Molecular Weight None
  • Synonym(s) 1-(5-Aminopyridin-2-YL)ethanone
  • SMILES CC(C1=NC=C(N)C=C1)=O

Description

1-(5-Aminopyridin-2-yl)ethan-1-one features a pyridine ring bearing a para-amino group and a ketone-functionalized ethyl side chain, enabling direct integration into heterocyclic scaffolds. This electron-rich moiety facilitates coupling reactions under mild conditions, offering a robust platform for synthesizing bioactive compounds in medicinal chemistry.

Application

1-(5-Aminopyridin-2-yl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. Its amine and ketone functionalities support diverse transformations, including reductive amination, condensation reactions, and further functionalization for heterocyclic scaffold development. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API discovery.

Synthesis

  • Route1
    • null|null
      75-16-1
    • In-stock
      5-Aminopicolinonitrile|CS-W016585
      55338-73-3
    • ~94%
    • In-stock
      1-(5-Aminopyridin-2-yl)ethan-1-one|CS-0142552
      51460-32-3

    References

    • Waller, Zoe A. E.; Shirude, Pravin S.; Rodriguez, Raphael; Balasubramanian, Shankar Chemical Communications, 2008 , # 12 p. 1467 - 1469

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   0.8664
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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