6-Fluoropyrimidin-4-amine

Name: 6-Fluoropyrimidin-4-amine
Brand: ChemScene
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CAS No. 51421-96-6
Cat. No. CS-0129426
Molecule weight113.09
Purity≥98%
MDL No.MFCD00769379

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 51421-96-6
Cat. No. CS-0129426
Purity ≥98%
MDL No. MFCD00769379
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄FN₃
Molecular Weight 113.09
Synonym(s) 4-Pyrimidinamine, 6-fluoro- (9CI)
SMILES NC1=NC=NC(F)=C1

Description

6-Fluoropyrimidin-4-amine features a fluorine atom at the 6-position and an amino group at the 4-position on a pyrimidine core, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into kinase inhibitors and antiviral agents, offering high reactivity in nucleophilic substitution and coupling reactions under standard conditions.

Application

6-Fluoropyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution or transition-metal-catalyzed coupling. Its fluorine substituent enhances metabolic stability and modulates electronic properties, while the amino group provides a handle for further derivatization. The compound exhibits good bench stability and facilitates efficient synthesis of kinase inhibitors and antiviral agents through established heterocyclic coupling protocols.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.8
LogP 0.1979
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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6-Fluoropyrimidin-4-amine

CAS No. 51421-96-6

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