6-Fluoro-5-methylpyrimidin-4-amine

Name: 6-Fluoro-5-methylpyrimidin-4-amine
Brand: ChemScene
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CAS No. 18260-69-0
Cat. No. CS-0097874
Molecule weight127.12
Purity≥97%
MDL No.MFCD10000602

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Fluoro-5-methylpyrimidin-4-amine|CS-0097874

Structure of 18260-69-0

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General Information

CAS No. 18260-69-0
Cat. No. CS-0097874
Purity ≥97%
MDL No. MFCD10000602
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆FN₃
Molecular Weight 127.12
Synonym(s) Pyrimidine, 4-amino-6-fluoro-5-methyl- (8CI)
SMILES NC1=NC=NC(F)=C1C

Description

6-Fluoro-5-methylpyrimidin-4-amine features a fluorinated pyrimidine core with a methyl group at the 5-position and an amine functionality at C4, enabling direct incorporation into bioactive heterocycles. This electron-deficient scaffold serves as a key building block in medicinal chemistry for targeted kinase inhibitors and antiviral agents.

Application

6-Fluoro-5-methylpyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrimidine-based scaffolds prevalent in kinase inhibitors and antiviral agents. The fluorine at C6 enhances metabolic stability and modulates electronic properties, while the methyl group at C5 provides steric and electronic tuning. Its amine functionality facilitates straightforward derivatization via coupling reactions, and the compound exhibits good bench stability and compatibility with standard synthetic protocols.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.8
LogP 0.50632
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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6-Fluoro-5-methylpyrimidin-4-amine

CAS No. 18260-69-0

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