Boc-Arg(di-Z)-OH

Name: Boc-Arg(di-Z)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 51219-19-3
Cat. No. CS-W013813
Purity≥98%
MDL No.MFCD00236824

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 51219-19-3

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Description

Boc-Arg(di-Z)-OH is a protected arginine derivative featuring a tert-butoxycarbonyl group and two benzyl protecting groups on the guanidine moiety. This configuration ensures stability during synthetic manipulations, enabling reliable incorporation into peptide chains under standard conditions. The di-Z protection prevents side reactions at the highly reactive guanidine nitrogen atoms, simplifying purification and handling in solid-phase peptide synthesis workflows.

Application

Boc-Arg(di-Z)-OH serves as a protected arginine building block for peptide synthesis, featuring orthogonal protection of the guanidino group with di-Z (diphenylmethyl) and the α-amino group with Boc. The di-Z group provides high stability under standard deprotection conditions, enabling selective manipulation during multi-step syntheses. This derivative facilitates efficient incorporation into complex peptides and peptidomimetics, offering excellent solubility and ease of purification, making it ideal for both academic and industrial-scale applications.

General Information

CAS No. 51219-19-3
Cat. No. CS-W013813
Purity ≥98%
MDL No. MFCD00236824
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₇H₃₄N₄O₈
Molecular Weight 542.58
Synonym(s) None
SMILES CC(C)(OC(N[C@H](C(O)=O)CCCN(C(OCC1=CC=CC=C1)=O)C(NC(OCC2=CC=CC=C2)=O)=N)=O)C

Computational Chemistry Data

TPSA 167.35
LogP 4.24447
H_Acceptors 8
H_Donors 4
Rotatable_Bonds 10

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Arginine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Boc-Arg(di-Z)-OH

CAS No. 51219-19-3

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