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Fmoc-norArg(Pbf)-OH

  • CAS No. 1313054-32-8

  • Cat. No. CS-0166823
  • Purity≥95%
  • MDL No.MFCD15142017

*For research and further manufacturing use only, not for direct human use.

Fmoc-norArg(Pbf)-OH|CS-0166823

Structure of 1313054-32-8

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General Information

  • CAS No. 1313054-32-8
  • Cat. No. CS-0166823
  • Purity ≥95%
  • MDL No. MFCD15142017
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₃H₃₈N₄O₇S
  • Molecular Weight 634.74
  • Synonym(s) (S,E)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(N'-((2,2,4,6,(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)butanoic acid
  • SMILES O=S(NC(NCC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=N)(C4=C(C)C(C)=C(OC(C)(C5)C)C5=C4C)=O

Description

Fmoc-norArg(Pbf)-OH is a protected arginine derivative featuring a Pbf-protected guanidino group and an Fmoc-labile α-amino block. This configuration enables efficient incorporation into peptide chains under standard coupling conditions, offering enhanced solubility and reduced side-reaction risks during solid-phase synthesis.

Application

Fmoc-norArg(Pbf)-OH serves as a key building block in solid-phase peptide synthesis, enabling efficient incorporation of norarginine residues with high fidelity. The Pbf (para-bromophenyl) protecting group ensures excellent orthogonality and stability during standard coupling conditions, while the Fmoc group allows for selective deprotection under mild basic conditions. This derivative exhibits robust bench stability, facilitates clean purification, and supports diverse functionalization in peptide sequences requiring basic side-chain functionality.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   155.42
  • LogP   4.51856
  • H_Acceptors   7
  • H_Donors   4
  • Rotatable_Bonds   11

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