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CS-W001157 4
Total: USD 88.00

5-(Hydroxymethyl)pyridin-3-ol

  • CAS No. 51035-70-2

  • Cat. No. CS-0094527
  • Purity≥98%
  • MDL No.MFCD12546435

*For research and further manufacturing use only, not for direct human use.

5-(Hydroxymethyl)pyridin-3-ol|CS-0094527

Structure of 51035-70-2

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General Information

  • CAS No. 51035-70-2
  • Cat. No. CS-0094527
  • Purity ≥98%
  • MDL No. MFCD12546435
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) 3-Pyridinemethanol,5-hydroxy-(9CI)
  • SMILES OCC1=CC(O)=CN=C1

Description

5-(Hydroxymethyl)pyridin-3-ol features a pyridine ring bearing both hydroxyl and hydroxymethyl groups at meta positions, enabling dual functionalization. This bifunctional scaffold integrates readily into synthetic sequences requiring polar, electron-rich sites. The compound demonstrates stability under standard conditions and supports efficient derivatization in medicinal chemistry and materials synthesis.

Application

5-(Hydroxymethyl)pyridin-3-ol serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its pyridine core provides a platform for metal-catalyzed coupling reactions, while the ortho-hydroxyl and hydroxymethyl groups enable efficient derivatization via etherification, oxidation, or protection strategies. The molecule exhibits good bench stability and facilitates straightforward purification, making it suitable for iterative synthetic sequences in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      958266-31-4
    • ~8%
    • In-stock
      5-(Hydroxymethyl)pyridin-3-ol|CS-0094527
      51035-70-2
    • null|null
      958266-32-5

    References

    • Rommel, Michael; Ernst, Alexander; Koert, Ulrich European Journal of Organic Chemistry, 2007 , # 26 p. 4408 - 4430
  • Route2

    References

    • Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226
  • Route3

    References

    • Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   0.2795
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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