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CS-W001157 4
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5-Methylpyrazine-2-carbaldehyde

  • CAS No. 50866-30-3

  • Cat. No. CS-W006037
  • Purity≥98%
  • MDL No.MFCD10697792

*For research and further manufacturing use only, not for direct human use.

5-Methylpyrazine-2-carbaldehyde|CS-W006037

Structure of 50866-30-3

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General Information

  • CAS No. 50866-30-3
  • Cat. No. CS-W006037
  • Purity ≥98%
  • MDL No. MFCD10697792
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O
  • Molecular Weight 122.13
  • Synonym(s) None
  • SMILES O=CC1=NC=C(C)N=C1

Description

5-Methylpyrazine-2-carbaldehyde features a pyrazine core with complementary methyl and aldehyde functionalities, enabling direct integration into heterocyclic scaffolds. This bench-stable compound serves as a key building block for bioactive molecule synthesis, particularly in agrochemical and pharmaceutical development.

Application

5-Methylpyrazine-2-carbaldehyde serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient access to pyrazine-based scaffolds. Its aldehyde functionality facilitates reductive amination, Grignard additions, and condensation reactions with amines or hydrazines. The methyl group provides mild steric and electronic modulation, enhancing metabolic stability in bioactive derivatives. Bench-stable and readily purified by flash chromatography, it functions reliably in multi-step syntheses of pharmaceutical intermediates and ligands.

Synthesis

  • Route1

    References

    • Kureha Chemical Industry Co., Ltd. Patent: EP1550657 A1, 2005 ; Location in patent: Page/Page column 73-74 ;
  • Route2

    References

    • Kastron, V.V.; Iovel', I.G.; Skrastyn'sh, I.P.; Gol'dberg, Yu.Sh.; Shimanskaya, M.V.; Dubur, G.Ya. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 8 p. 915 - 917 Khimiya Geterotsiklicheskikh Soedinenii, 1986 , # 8 p. 1124 - 1126
  • Route3
    • 2,5-Dimethylpyrazine Glipizide  Impurity|CS-0229015
      123-32-0
    • ~37%
    • In-stock
      Pyrazine-2,5-dicarbaldehyde|CS-0169818
      77666-94-5
    • In-stock
      5-Methylpyrazine-2-carbaldehyde|CS-W006037
      50866-30-3

    References

    • Iovel', I. G.; Yansone, I. Ya.; Gol'dberg, Yu. Sh.; Shimanskaya, M. V. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 4 p. 456 - 461 Khimiya Geterotsiklicheskikh Soedinenii, 1990 , # 4 p. 532 - 537

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   42.85
  • LogP   0.59752
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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