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Methyl 5-methylpyrazine-2-carboxylate

  • CAS No. 41110-33-2

  • Cat. No. CS-0038852
  • Purity≥97%
  • MDL No.MFCD04116910

*For research and further manufacturing use only, not for direct human use.

Methyl 5-methylpyrazine-2-carboxylate|CS-0038852

Structure of 41110-33-2

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General Information

  • CAS No. 41110-33-2
  • Cat. No. CS-0038852
  • Purity ≥97%
  • MDL No. MFCD04116910
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₂
  • Molecular Weight 152.15
  • Synonym(s) 2-Pyrazinecarboxylic acid, 5-methyl-, methyl ester
  • SMILES CC1=NC=C(C(=O)OC)N=C1

Description

Methyl 5-methylpyrazine-2-carboxylate features a pyrazine core with complementary methyl and ester functionalities, enabling direct integration into heterocyclic synthesis. This bench-stable, moisture-tolerant reagent facilitates efficient access to bioactive scaffolds through cross-coupling and cyclization protocols.

Application

Methyl 5-methylpyrazine-2-carboxylate serves as a versatile building block in medicinal and agrochemical synthesis, enabling efficient access to pyrazine-based scaffolds. Its methyl ester functionality facilitates straightforward derivatization via hydrolysis or nucleophilic substitution, while the electron-deficient pyrazine ring supports transition metal-catalyzed couplings. The molecule exhibits excellent bench stability and is readily purified by flash chromatography, making it well-suited for multi-step synthetic sequences in industrial R&D settings.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      5-Methylpyrazine-2-carboxylic acid|CS-0007012
      5521-55-1
    • ~93%
    • In-stock
      Methyl 5-methylpyrazine-2-carboxylate|CS-0038852
      41110-33-2

    References

    • ISP INVESTMENTS INC. Patent: US2005/261312 A1, 2005 ; Location in patent: Page/Page column 2 ;
  • Route2
    • null|null
      67-56-1
    • null|null
      950993-55-2
    • ~73%
    • In-stock
      Methyl 5-methylpyrazine-2-carboxylate|CS-0038852
      41110-33-2

    References

    • Mamane, Victor; Aubert, Emmanuel; Fort, Yves Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7294 - 7300
  • Route3

    References

    • Kureha Chemical Industry Co., Ltd. Patent: EP1273571 A1, 2003 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   0.57162
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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