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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-(Trifluoromethyl)phenylboronic acid

  • CAS No. 503309-11-3

  • Cat. No. CS-D1023
  • Purity≥97%
  • MDL No.MFCD03094995

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-(Trifluoromethyl)phenylboronic acid|CS-D1023

Structure of 503309-11-3

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General Information

  • CAS No. 503309-11-3
  • Cat. No. CS-D1023
  • Purity ≥97%
  • MDL No. MFCD03094995
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BF₄O₂
  • Molecular Weight 207.92
  • Synonym(s) 2-Fluoro-4-(trifluoromethyl)benzeneboronicacid
  • SMILES FC(C1=CC=C(B(O)O)C(F)=C1)(F)F

Description

2-Fluoro-4-(trifluoromethyl)phenylboronic acid features a boronate moiety appended to an electron-deficient aryl ring, enabling efficient Suzuki-Miyaura coupling under standard conditions. The trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the ortho-fluorine facilitates directed functionalization. This bench-stable reagent integrates readily into complex molecule synthesis, particularly in pharmaceutical and agrochemical discovery workflows.

Application

2-Fluoro-4-(trifluoromethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its fluorinated aryl core enhances metabolic stability and modulates electronic properties, while the boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions. Ideal for medicinal chemistry and materials science applications requiring halogenated, electron-deficient aryl linkages.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.5243
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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