(2-Fluoro-5-(trifluoromethyl)phenyl)boronic acid

Name: (2-Fluoro-5-(trifluoromethyl)phenyl)boronic acid
Brand: ChemScene
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CAS No. 352535-96-7
Cat. No. CS-W015251
Purity≥97%
MDL No.MFCD03701538

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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(2-Fluoro-5-(trifluoromethyl)phenyl)boronic acid|CS-W015251

Structure of 352535-96-7

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General Information

CAS No. 352535-96-7
Cat. No. CS-W015251
Purity ≥97%
MDL No. MFCD03701538
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BF₄O₂
Molecular Weight 207.92
Synonym(s) 2-Fluoro-5-(trifluoromethyl)phenylboronic acid
SMILES OB(C1=CC(C(F)(F)F)=CC=C1F)O

Description

This boronic acid features a fluorinated aryl scaffold with a trifluoromethyl group at the para position, enhancing electronic withdrawal and metabolic stability. The pendant boronic acid moiety enables efficient Suzuki-Miyaura coupling under standard conditions, delivering high-yielding cross-coupling products in diverse synthetic applications.

Application

(2-Fluoro-5-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. Its stability under ambient conditions and tolerance to various functional groups facilitate straightforward synthesis of fluorinated aromatic scaffolds relevant to pharmaceutical and agrochemical development.

Synthesis

Route1
- 7647-01-0
- 121-43-7
- 1232367-11-1
- ~%
- In-stock
  
  352535-96-7
References
- US2011/224457 A1, ; Page/Page column 12 ;
Route2
- 402-44-8
- ~%
- In-stock
  
  352535-96-7
References
- US2011/224457 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

TPSA 40.46
LogP 0.5243
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Synthesis Organometallic Reagents Organoboron Boronic Acids and Derivatives

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(2-Fluoro-5-(trifluoromethyl)phenyl)boronic acid

CAS No. 352535-96-7

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