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CS-W001157 4
Total: USD 88.00

4-(tert-Butoxycarbonyl)thiomorpholine-2-carboxylic acid

  • CAS No. 134676-67-8

  • Cat. No. CS-0097843
  • Purity≥97%
  • MDL No.MFCD03426523

*For research and further manufacturing use only, not for direct human use.

4-(tert-Butoxycarbonyl)thiomorpholine-2-carboxylic acid|CS-0097843

Structure of 134676-67-8

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General Information

  • CAS No. 134676-67-8
  • Cat. No. CS-0097843
  • Purity ≥97%
  • MDL No. MFCD03426523
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₄S
  • Molecular Weight 247.31
  • Synonym(s) N-Boc-2-thioMorpholinecarboxylic Acid
  • SMILES O=C(O)C1CN(CCS1)C(OC(C)(C)C)=O

Description

4-(tert-Butoxycarbonyl)thiomorpholine-2-carboxylic acid features a protected thiomorpholine-2-carboxylic acid scaffold with a robust tert-butoxycarbonyl group, enabling stable incorporation into peptide synthesis. The electron-deficient sulfur atom enhances reactivity in coupling reactions, while the steric bulk of the tert-butyl moiety minimizes side reactions. This derivative facilitates efficient access to bioactive thiomorpholine-containing compounds under standard conditions.

Application

4-(tert-Butoxycarbonyl)thiomorpholine-2-carboxylic acid serves as a stable, bench-ready building block for the synthesis of thiomorpholine-based heterocycles. The Boc-protected carboxylic acid functionality enables straightforward deprotection and coupling reactions, facilitating access to diverse pharmaceutical scaffolds. Its functional group tolerance supports integration into multi-step synthetic sequences, particularly in medicinal chemistry campaigns targeting kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.4235
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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