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CS-W001157 4
Total: USD 88.00

Glycine-N-methylamide hydrochloride

  • CAS No. 49755-94-4

  • Cat. No. CS-0130384
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Glycine-N-methylamide hydrochloride|CS-0130384

Structure of 49755-94-4

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General Information

  • CAS No. 49755-94-4
  • Cat. No. CS-0130384
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉ClN₂O
  • Molecular Weight 124.57
  • Synonym(s) N-Methylglycinamidehydrochloride
  • SMILES NCC(NC)=O.Cl

Description

Glycine-N-methylamide hydrochloride delivers a stable, moisture-tolerant amide derivative ideal for peptide synthesis and chemical biology applications. This N-terminally modified glycine unit integrates seamlessly into C-terminal extensions, offering enhanced solubility and controlled reactivity under standard conditions.

Application

Glycine-N-methylamide hydrochloride serves as a versatile building block in peptide synthesis and medicinal chemistry, offering a stable, bench-ready source of the N-methylglycine amide moiety. Its zwitterionic character and crystalline form facilitate handling and purification, while the protected amine enables selective coupling reactions. This derivative functions effectively in the construction of bioactive peptides and heterocyclic scaffolds, providing enhanced metabolic stability compared to native glycine.

Synthesis

  • Route1
    • tert-Butyl 2-(methylamino)-2-oxoethylcarbamate|CS-0210071
      88815-85-4
    • ~%
    • In-stock
      Glycine-N-methylamide hydrochloride|CS-0130384
      49755-94-4

    References

    • NIMBUS IRIS, INC.; HARRIMAN, Geraldine, C.; WESTER, Ronald T.; ROMERO, Donna L.; ROBINSON, Shaughnessy; SHELLEY, Mee; WESSEL, Matthew David; GREENWOOD, Jeremy Robert; MASSE, Craig E.; KAPELLER-LIBERMANN, Rosana Patent: WO2013/106535 A1, 2013 ; Location in patent: Paragraph 00571 ;
  • Route2
    • In-stock
      Glycine ethyl ester monohydrochloride|CS-W020007
      623-33-6
    • null|null
      74-89-5
    • ~99%
    • In-stock
      Glycine-N-methylamide hydrochloride|CS-0130384
      49755-94-4

    References

    • Ranieri, Kayte; Conradi, Matthias; Chavant, Pierre-Yves; Blandin, Veronique; Barner-Kowollik, Christopher; Junkers, Thomas Australian Journal of Chemistry, 2012 , vol. 65, # 8 p. 1110 - 1116
  • Route3
    • In-stock
      Methyl 2-aminoacetate hydrochloride|CS-W018508
      5680-79-5
    • null|null
      74-89-5
    • ~%
    • In-stock
      Glycine-N-methylamide hydrochloride|CS-0130384
      49755-94-4

    References

    • NIMBUS IRIS, INC.; HARRIMAN, Geraldine, C.; WESTER, Ronald T.; ROMERO, Donna L.; ROBINSON, Shaughnessy; SHELLEY, Mee; WESSEL, Matthew David; GREENWOOD, Jeremy Robert; MASSE, Craig E.; KAPELLER-LIBERMANN, Rosana Patent: WO2013/106535 A1, 2013 ; Location in patent: Paragraph 00569 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.8871
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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