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4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

  • CAS No. 494767-29-2

  • Cat. No. CS-D0299
  • Purity≥98%
  • MDL No.MFCD11518937

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine|CS-D0299

Structure of 494767-29-2

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General Information

  • CAS No. 494767-29-2
  • Cat. No. CS-D0299
  • Purity ≥98%
  • MDL No. MFCD11518937
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂
  • Molecular Weight 154.60
  • Synonym(s) 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride
  • SMILES ClC1=NC=CC2=C1CCN2

Description

4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is a heterocyclic scaffold featuring a chlorinated pyrrolopyridine core with enhanced electron-deficient character. This bench-stable, moisture-tolerant compound integrates readily into medicinal chemistry campaigns, serving as a key building block for kinase inhibitors and bioactive small molecules.

Application

4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused pyrrolopyridine scaffolds. Its chloro substituent facilitates palladium-catalyzed cross-coupling reactions, while the dihydro-pyrrolopyridine core offers moderate stability and favorable functional group tolerance. The compound functions effectively in standard synthetic workflows for constructing bioactive molecules, particularly in kinase inhibitor and CNS-targeted drug discovery programs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.703
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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