1,3-Dimethyl-1H-pyrazole-5-methanamine

Name: 1,3-Dimethyl-1H-pyrazole-5-methanamine
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CAS No. 499770-63-7
Cat. No. CS-B1324
Purity≥98%
MDL No.MFCD02682038

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1,3-Dimethyl-1H-pyrazole-5-methanamine|CS-B1324

Structure of 499770-63-7

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General Information

CAS No. 499770-63-7
Cat. No. CS-B1324
Purity ≥98%
MDL No. MFCD02682038
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁N₃
Molecular Weight 125.17
Synonym(s) ((2,5-Dimethyl-2H-pyrazol-3-yl)methyl)amine; (1,3-Dimethyl-1H-pyrazol-5-yl)methanamine; 3-Aminomethyl-2,5-dimethyl-2H-pyrazole; 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine
SMILES CC1=NN(C)C(CN)=C1

Description

1,3-Dimethyl-1H-pyrazole-5-methanamine features a pyrazole core functionalized with methyl groups at the 1- and 3-positions and a methanamine side chain at the 5-position. This configuration imparts enhanced solubility and nucleophilicity, enabling efficient incorporation into bioconjugation workflows and modular synthesis of heterocyclic scaffolds under standard conditions.

Application

1,3-Dimethyl-1H-pyrazole-5-methanamine serves as a versatile scaffold for medicinal chemistry and catalyst design, offering a readily functionalizable pyrazole core with orthogonal reactivity. The pendant primary amine enables conjugation via amidation or alkylation, while the methylated positions enhance metabolic stability and solubility. This compound facilitates efficient synthesis of heterocyclic building blocks and demonstrates robust bench stability, making it well-suited for iterative library construction and process-scale applications.

Synthesis

Route1
- In-stock
  
  306936-77-6
- ~%
- In-stock
  
  499770-63-7
References
- WO2004/56806 A1, ; Page 80 ; WO 2004/056806 A1
Route2
- 1182281-77-1
- ~%
- In-stock
  
  499770-63-7
References
- WO2009/101082 A1, ; Page/Page column 72 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 43.84
LogP 0.18722
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1,3-Dimethyl-1H-pyrazole-5-methanamine

CAS No. 499770-63-7

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