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CS-W001157 4
Total: USD 88.00

3-Chloro-[1,2,4]triazolo[4,3-a]pyridine

  • CAS No. 4922-74-1

  • Cat. No. CS-0051427
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Chloro-[1,2,4]triazolo[4,3-a]pyridine|CS-0051427

Structure of 4922-74-1

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General Information

  • CAS No. 4922-74-1
  • Cat. No. CS-0051427
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClN₃
  • Molecular Weight 153.57
  • Synonym(s) 3-Chloro[1,2,4]triazolo[4,3-a]pyridine
  • SMILES ClC1=NN=C2C=CC=CN12

Description

3-Chloro-[1,2,4]triazolo[4,3-a]pyridine is a heterocyclic scaffold featuring a fused triazolopyridine core with a chloro substituent at the 3-position. This electron-deficient system serves as a key building block in medicinal chemistry, enabling efficient coupling reactions and offering enhanced metabolic stability in bioactive molecule design.

Application

3-Chloro-[1,2,4]triazolo[4,3-a]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of triazolopyridine scaffolds. Its chlorine substituent facilitates nucleophilic substitution reactions under mild conditions, supporting the rapid diversification of core structures. The compound exhibits excellent bench stability and compatibility with common functional groups, making it well-suited for modular synthesis workflows in API development and target-oriented drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.3827
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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