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CS-W001157 4
Total: USD 88.00

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine

  • CAS No. 4922-68-3

  • Cat. No. CS-W008906
  • Purity≥95%
  • MDL No.MFCD11111699

*For research and further manufacturing use only, not for direct human use.

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine|CS-W008906

Structure of 4922-68-3

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General Information

  • CAS No. 4922-68-3
  • Cat. No. CS-W008906
  • Purity ≥95%
  • MDL No. MFCD11111699
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrN₃
  • Molecular Weight 198.02
  • Synonym(s) 3-Bromo[1,2,4]triazolo[4,3-a]pyridine
  • SMILES BrC1=NN=C2C=CC=CN21

Description

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine is a heterocyclic building block featuring a brominated triazolopyridine core, enabling direct functionalization in cross-coupling reactions. The electron-deficient pyridine ring enhances reactivity in palladium-catalyzed transformations, while the bench-stable bromide serves as a versatile handle for C–C and C–heteroatom bond formation.

Application

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling direct functionalization via palladium-catalyzed cross-coupling reactions. Its bromine substituent facilitates C–C and C–heteroatom bond formation under standard conditions, while the fused triazolopyridine core provides metabolic stability and favorable pharmacophore characteristics. The compound exhibits excellent bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis of complex nitrogen-containing scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.4918
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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