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CS-W001157 4
Total: USD 88.00

Propargyl-PEG1-Boc

  • CAS No. 488150-84-1

  • Cat. No. CS-0114528
  • Purity≥97%
  • MDL No.MFCD26793744

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG1-Boc|CS-0114528

Structure of 488150-84-1

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General Information

  • CAS No. 488150-84-1
  • Cat. No. CS-0114528
  • Purity ≥97%
  • MDL No. MFCD26793744
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆O₃
  • Molecular Weight 184.23
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)CCOCC#C

Description

Propargyl-PEG1-Boc features a terminal alkyne group flanked by a short PEG spacer and a stable Boc protecting group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) under mild conditions. This bifunctional architecture facilitates site-specific conjugation in bioconjugation workflows while maintaining compatibility with aqueous environments and standard synthetic protocols.

Application

Propargyl-PEG1-Boc serves as a versatile bifunctional building block for conjugation and protection strategies in synthetic chemistry. The propargyl group enables efficient CuAAC "click" reactions, while the Boc-protected amine offers orthogonal handling under basic conditions. This combination facilitates modular synthesis of peptide- and polymer-conjugates with high stability and ease of purification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.368
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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