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Propargyl-PEG4-CH2CH2-Boc

  • CAS No. 1245823-50-0

  • Cat. No. CS-0106532
  • Purity≥97%
  • MDL No.MFCD22201534

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG4-CH2CH2-Boc|CS-0106532

Structure of 1245823-50-0

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General Information

  • CAS No. 1245823-50-0
  • Cat. No. CS-0106532
  • Purity ≥97%
  • MDL No. MFCD22201534
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₃₂O₇
  • Molecular Weight 360.44
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

Description

Propargyl-PEG4-CH2CH2-Boc features a terminal alkyne for click chemistry, flanked by a hydrophilic PEG4 spacer and a stable Boc-protected amine. This bifunctional scaffold enables efficient conjugation while maintaining solubility and compatibility with standard synthetic workflows.

Application

Propargyl-PEG4-CH2CH2-Boc serves as a versatile bifunctional linker for conjugation and protection strategies in synthetic chemistry. The propargyl group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the Boc-protected amine offers orthogonal handling. The PEG4 spacer provides solubility and reduces aggregation, enhancing utility in peptide modification, probe synthesis, and macrocyclic scaffold construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   72.45
  • LogP   1.4344
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   16

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