4-Chloro-6-methoxy-2-methylpyrimidine

Name: 4-Chloro-6-methoxy-2-methylpyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 89466-39-7
Cat. No. CS-0030466
Purity≥98%
MDL No.MFCD16768933

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-6-methoxy-2-methylpyrimidine|CS-0030466

Structure of 89466-39-7

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General Information

CAS No. 89466-39-7
Cat. No. CS-0030466
Purity ≥98%
MDL No. MFCD16768933
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) None
SMILES CC1=NC(OC)=CC(Cl)=N1

Description

4-Chloro-6-methoxy-2-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a chlorinated position at C4 and a methoxy group at C6. This electron-deficient pyrimidine core integrates readily into kinase inhibitors and antiviral agents. The methyl substitution at C2 enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench-stability and compatibility with standard coupling reactions under mild conditions.

Application

4-Chloro-6-methoxy-2-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and cross-coupling reactions. The chloro group at C4 provides a reliable handle for functionalization, while the methoxy and methyl substituents enhance solubility and modulate electronic properties. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for multi-step synthesis and process development workflows.

Synthesis

Route1
- 1780-26-3
- 124-41-4
- ~%
- In-stock
  
  89466-39-7
References
- Nezu, Yukio; Miyazaki, Masahiro; Sugiyama, Kazuhiko; Kajiwara, Ikuo Pesticide Science, 1996 , vol. 47, # 2 p. 103 - 114

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.01
LogP 1.44702
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chloro-6-methoxy-2-methylpyrimidine

CAS No. 89466-39-7

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