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CS-W001157 4
Total: USD 88.00

3-Fluorobenzamide

  • CAS No. 455-37-8

  • Cat. No. CS-0088533
  • Purity≥97%
  • MDL No.MFCD00007983

*For research and further manufacturing use only, not for direct human use.

3-Fluorobenzamide|CS-0088533

Structure of 455-37-8

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General Information

  • CAS No. 455-37-8
  • Cat. No. CS-0088533
  • Purity ≥97%
  • MDL No. MFCD00007983
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) M-FLUOROBENZAMIDE
  • SMILES O=C(N)C1=CC=CC(F)=C1

Description

3-Fluorobenzamide serves as a key aryl amide building block in medicinal chemistry, offering enhanced metabolic stability and improved membrane permeability. The meta-fluoro substitution imparts favorable electronic properties for target engagement, while the amide functionality enables direct incorporation into peptide-like scaffolds or coupling reactions under standard conditions.

Application

3-Fluorobenzamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic scaffolds into target molecules. Its amide functionality offers enhanced metabolic stability and favorable polarity profiles, while the ortho-fluoro substituent facilitates downstream functionalization via nucleophilic aromatic substitution or transition-metal-catalyzed coupling. Bench-stable and readily purified by crystallization, it functions effectively in standard peptide coupling and heterocycle synthesis workflows.

Synthesis

  • Route1

    References

    • Louvel, Julien; Guo, Dong; Agliardi, Marta; Mocking, Tamara A. M.; Kars, Roland; Pham, Tan Phat; Xia, Lizi; De Vries, Henk; Brussee, Johannes; Heitman, Laura H.; Ijzerman, Adriaan P. Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3213 - 3222
  • Route2

    References

    • Song, Qiuling; Feng, Qiang; Yang, Kai Organic Letters, 2014 , vol. 16, # 2 p. 624 - 627
  • Route3
    • (R)-2-(3-Fluorophenyl)-2-hydroxyacetic acid|CS-0899139
      32222-47-2
    • ~58%
    • In-stock
      3-Fluorobenzamide|CS-0088533
      455-37-8

    References

    • Song, Qiuling; Feng, Qiang; Yang, Kai Organic Letters, 2014 , vol. 16, # 2 p. 624 - 627

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   0.9246
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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