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CS-W001157 4
Total: USD 88.00

1-Boc-3-Methylaminopyrrolidine

  • CAS No. 454712-26-6

  • Cat. No. CS-W000365
  • Purity≥95%
  • MDL No.MFCD06656606

*For research and further manufacturing use only, not for direct human use.

1-Boc-3-Methylaminopyrrolidine|CS-W000365

Structure of 454712-26-6

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General Information

  • CAS No. 454712-26-6
  • Cat. No. CS-W000365
  • Purity ≥95%
  • MDL No. MFCD06656606
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight None
  • Synonym(s) tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate
  • SMILES CNC1CCN(C1)C(=O)OC(C)(C)C

Description

1-Boc-3-Methylaminopyrrolidine delivers a protected amine handle for late-stage functionalization in medicinal chemistry. The Boc group ensures stability during synthesis and purification, while the pyrrolidine core provides conformational rigidity and enhanced solubility. This intermediate integrates seamlessly into diverse molecular architectures.

Application

1-Boc-3-methylaminopyrrolidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrrolidine-based scaffolds through mild deprotection. The Boc group provides excellent bench stability and facilitates purification, while the tertiary amine functionality supports diverse functionalization via alkylation or reductive amination. Its compatibility with standard coupling and protection protocols makes it ideal for constructing bioactive heterocycles and peptide mimetics in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.2152
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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