Lot numbers can be found on the outside label of a product:
1-Acetyl-6-amino-3,3-dimethylindoline
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CAS No. 453562-71-5
- Cat. No. CS-M3748
- Purity≥97%
- MDL No.MFCD07636699
*For research and further manufacturing use only, not for direct human use.
Structure of 453562-71-5
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General Information
- CAS No. 453562-71-5
- Cat. No. CS-M3748
- Purity ≥97%
- MDL No. MFCD07636699
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₆N₂O
- Molecular Weight 204.27
- Synonym(s) 1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone
- SMILES NC1=CC2=C(C=C1)C(C)(C)CN2C(C)=O
Description
1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone features a sterically hindered indolinone core with a pendant amino group, enabling direct integration into peptide and heterocyclic scaffolds. The acetyl moiety provides a reactive handle for derivatization under mild conditions, while the electron-rich aromatic system enhances solubility in polar organic solvents. This compound serves as a key building block for bioactive molecule synthesis.
Application
1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling the construction of indoline-based scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The acetamide functionality provides a handle for derivatization via acylation or reductive amination, while the 3,3-dimethyl substitution enhances metabolic stability and modulates solubility. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses requiring functional group tolerance and predictable reactivity.
Synthesis
Safety Information
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Quality Control
Computational Chemistry Data
- TPSA 46.33
- LogP 1.9129
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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