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CS-W001157 4
Total: USD 88.00

1-Acetyl-6-amino-3,3-dimethylindoline

  • CAS No. 453562-71-5

  • Cat. No. CS-M3748
  • Purity≥97%
  • MDL No.MFCD07636699
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Acetyl-6-amino-3,3-dimethylindoline|CS-M3748

Structure of 453562-71-5

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Description

1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone features a sterically hindered indolinone core with a pendant amino group, enabling direct integration into peptide and heterocyclic scaffolds. The acetyl moiety provides a reactive handle for derivatization under mild conditions, while the electron-rich aromatic system enhances solubility in polar organic solvents. This compound serves as a key building block for bioactive molecule synthesis.

Application

1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling the construction of indoline-based scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The acetamide functionality provides a handle for derivatization via acylation or reductive amination, while the 3,3-dimethyl substitution enhances metabolic stability and modulates solubility. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses requiring functional group tolerance and predictable reactivity.

General Information

  • CAS No. 453562-71-5
  • Cat. No. CS-M3748
  • Purity ≥97%
  • MDL No. MFCD07636699
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆N₂O
  • Molecular Weight 204.27
  • Synonym(s) 1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone
  • SMILES NC1=CC2=C(C=C1)C(C)(C)CN2C(C)=O

Computational Chemistry Data

  • TPSA   46.33
  • LogP   1.9129
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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