Lot numbers can be found on the outside label of a product:
2-Bromo-6-methyl-4-(trifluoromethyl)pyridine
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CAS No. 451459-17-9
- Cat. No. CS-0173548
- Purity≥96%
- MDL No.MFCD07368051
*For research and further manufacturing use only, not for direct human use.
Structure of 451459-17-9
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General Information
- CAS No. 451459-17-9
- Cat. No. CS-0173548
- Purity ≥96%
- MDL No. MFCD07368051
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅BrF₃N
- Molecular Weight 240.02
- Synonym(s) 2-Bromor-6-methyl-4-trifluoromethylpyridine
- SMILES FC(C1=CC(Br)=NC(C)=C1)(F)F
Description
2-Bromo-6-methyl-4-(trifluoromethyl)pyridine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the bromo and methyl substituents provide orthogonal handles for cross-coupling and regioselective functionalization. This scaffold enables efficient integration into pharmaceutical intermediates and advanced materials.
Application
2-Bromo-6-methyl-4-(trifluoromethyl)pyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity at the bromo position. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides steric and electronic modulation. Its bench-stable nature and compatibility with diverse functional groups make it suitable for constructing complex pyridine-based scaffolds in medicinal chemistry and agrochemical research.
Synthesis
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Route1
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In-stock
22123-19-9 -
7789-60-8 - ~43%
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In-stock
451459-17-9
References
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Dalton Transactions, , vol. 42, # 38 p. 13882 - 13888
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Route2
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367-57-7
- ~%
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In-stock
451459-17-9
References
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Dalton Transactions, , vol. 42, # 38 p. 13882 - 13888
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Route3
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In-stock
654-49-9 - ~%
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In-stock
451459-17-9
References
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Dalton Transactions, , vol. 42, # 38 p. 13882 - 13888
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 3.17132
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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