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CS-W001157 4
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1-(2-Amino-3-hydroxyphenyl)ethanone

  • CAS No. 4502-10-7

  • Cat. No. CS-0033833
  • Molecule weight151.16
  • Purity≥98%
  • MDL No.MFCD00191301

*For research and further manufacturing use only, not for direct human use.

1-(2-Amino-3-hydroxyphenyl)ethanone|CS-0033833

Structure of 4502-10-7

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General Information

  • CAS No. 4502-10-7
  • Cat. No. CS-0033833
  • Purity ≥98%
  • MDL No. MFCD00191301
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₂
  • Molecular Weight 151.16
  • Synonym(s) None
  • SMILES CC(C1=CC=CC(O)=C1N)=O

Description

This 1-(2-Amino-3-hydroxyphenyl)ethanone features a benzene ring bearing both amino and hydroxyl groups in ortho positions relative to the acetyl side chain, enabling strong hydrogen bonding and enhanced solubility. The conjugated carbonyl integrates readily into synthetic intermediates for pharmaceuticals and functional materials.

Application

1-(2-Amino-3-hydroxyphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocyclic scaffolds. Its ortho-dihydroxy-aniline functionality supports metal-catalyzed coupling reactions and facilitates oxidative cyclization pathways. The compound exhibits good bench stability and tolerates common functional groups, making it suitable for multi-step synthesis workflows requiring precise regiocontrol and compatibility with standard protecting group strategies.

Synthesis

  • Route1

    References

    • Journal of Heterocyclic Chemistry, , vol. 34, # 5 p. 1407 - 1414
  • Route2

    References

    • Journal of Natural Products, , vol. 61, # 6 p. 821 - 822
  • Route3

    References

    • Gazzetta Chimica Italiana, , vol. 80, p. 161,169

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.177
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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