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CS-W001157 4
Total: USD 88.00

4-Morpholinepropionic acid

  • CAS No. 4497-04-5

  • Cat. No. CS-0033769
  • Purity≥97%
  • MDL No.MFCD02089311

*For research and further manufacturing use only, not for direct human use.

4-Morpholinepropionic acid|CS-0033769

Structure of 4497-04-5

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General Information

  • CAS No. 4497-04-5
  • Cat. No. CS-0033769
  • Purity ≥97%
  • MDL No. MFCD02089311
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₃
  • Molecular Weight 159.18
  • Synonym(s) 3-Morpholinopropanoic acid
  • SMILES O=C(O)CCN1CCOCC1

Description

4-Morpholinepropionic acid combines a morpholine ring with a propionic acid side chain, offering enhanced solubility and metabolic stability. This structure facilitates integration into bioactive molecules, where the polar morpholine moiety improves pharmacokinetic profiles while the carboxylic acid enables conjugation or salt formation under standard conditions.

Application

4-Morpholinepropionic acid serves as a versatile building block in medicinal chemistry, offering a balanced combination of solubility and metabolic stability. Its morpholine ring provides hydrogen-bonding capacity and favorable pharmacokinetic properties, while the propionic acid moiety enables straightforward derivatization via amide or ester formation. The molecule exhibits excellent bench stability and is compatible with standard coupling conditions, facilitating integration into diverse synthetic sequences including peptide and heterocyclic scaffold construction.

Synthesis

  • Route1
    • Methyl 3-morpholinopropionate|CS-0204262
      33611-43-7
    • ~89%
    • In-stock
      4-Morpholinepropionic acid|CS-0033769
      4497-04-5

    References

    • US6184225 B2, ;
  • Route2
    • null|null
      110-91-8
    • null|null
      292638-85-8
    • ~80%
    • In-stock
      4-Morpholinepropionic acid|CS-0033769
      4497-04-5

    References

    • Russian Chemical Bulletin, , vol. 47, # 9 p. 1732 - 1735
  • Route3

    References

    • US2526558 , ; Journal of the American Chemical Society, , vol. 73, p. 3168,3171

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   -0.2067
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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