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CS-W001157 4
Total: USD 88.00

2-Hydroxy-1-morpholin-4-ylethanone

  • CAS No. 51068-78-1

  • Cat. No. CS-0028591
  • Purity≥97%
  • MDL No.MFCD08436413

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-1-morpholin-4-ylethanone|CS-0028591

Structure of 51068-78-1

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General Information

  • CAS No. 51068-78-1
  • Cat. No. CS-0028591
  • Purity ≥97%
  • MDL No. MFCD08436413
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₃
  • Molecular Weight 145.16
  • Synonym(s) 2-Morpholin-4-YL-2-oxoethanol
  • SMILES OCC(N1CCOCC1)=O

Description

2-Hydroxy-1-morpholin-4-ylethanone features a morpholin-4-yl group flanked by a hydroxyl and ketone, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block for pharmaceutical intermediates and functional materials.

Application

2-Hydroxy-1-morpholin-4-ylethanone serves as a versatile synthon in medicinal chemistry, enabling efficient construction of morpholine-containing heterocycles. Its α-hydroxy ketone functionality facilitates nucleophilic addition and cyclization reactions under mild conditions, offering reliable access to bioactive scaffolds. The molecule exhibits bench stability and compatibility with common protecting group strategies, supporting its use in multi-step synthesis workflows.

Synthesis

  • Route1

    References

    • SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.; DE BOER, Eric Johannes Maria; VAN DER HEIJDEN, Harry; MEURS, Jan Hermen Hendrik; WIJNANS, Sanne Patent: WO2010/130696 A1, 2010 ; Location in patent: Page/Page column 10-12 ;
  • Route2
    • null|null
      110-91-8
    • null|null
      4158-86-5
    • ~96%
    • In-stock
      2-Hydroxy-1-morpholin-4-ylethanone|CS-0028591
      51068-78-1

    References

    • Boyko, Vyacheslav I.; Rodik, Roman V.; Severenchuk, Inna N.; Voitenko, Zoya V.; Kalchenko, Vitaly I. Synthesis, 2007 , # 14 p. 2095 - 2096
  • Route3
    • null|null
      110-91-8
    • In-stock
      Methyl 2-hydroxyacetate|CS-W004068
      96-35-5
    • ~%
    • In-stock
      2-Hydroxy-1-morpholin-4-ylethanone|CS-0028591
      51068-78-1

    References

    • Baindur, Nand; Gaul, Michael David; Kreutter, Kevin Douglas; Baumann, Christian Andrew; Kim, Alexander J.; Xu, Guozhang; Tuman, Robert W.; Johnson, Dana L. Patent: US2006/281772 A1, 2006 ; Location in patent: Page/Page column 120 ; US 20060281772 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   -1.1625
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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