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CS-W001157 4
Total: USD 88.00

4-(3-Hydroxypropyl)morpholine

  • CAS No. 4441-30-9

  • Cat. No. CS-W002821
  • Purity≥97%
  • MDL No.MFCD01713533

*For research and further manufacturing use only, not for direct human use.

4-(3-Hydroxypropyl)morpholine|CS-W002821

Structure of 4441-30-9

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General Information

  • CAS No. 4441-30-9
  • Cat. No. CS-W002821
  • Purity ≥97%
  • MDL No. MFCD01713533
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO₂
  • Molecular Weight 145.20
  • Synonym(s) 3-Morpholinopropanol
  • SMILES OCCCN1CCOCC1

Description

4-(3-Hydroxypropyl)morpholine is a bench-stable, moisture-tolerant heterocyclic amine featuring a primary hydroxyl group pendant to the morpholine ring. This functionalized scaffold integrates readily into conjugation workflows and serves as a solubilizing handle in bioconjugate synthesis.

Application

4-(3-Hydroxypropyl)morpholine serves as a versatile bifunctional building block in medicinal chemistry, combining a morpholine ring with a primary alcohol for downstream derivatization. The hydroxyl group enables facile etherification, esterification, or conjugation, while the morpholine nitrogen supports hydrogen bonding and solubility enhancement. This compound exhibits good bench stability and is compatible with standard purification techniques, facilitating its use in constructing complex heterocyclic scaffolds and optimizing pharmacokinetic properties in lead compounds.

Synthesis

  • Route1
    • null|null
      110-91-8
    • In-stock
      3-Bromopropan-1-ol|CS-W007337
      627-18-9
    • ~51%
    • In-stock
      4-(3-Hydroxypropyl)morpholine|CS-W002821
      4441-30-9

    References

    • Zeneca Limited Patent: US6265411 B1, 2001 ;
  • Route2
    • ethyl 3-morpholin-4-ylpropanoate|CS-0038645
      20120-24-5
    • ~75%
    • In-stock
      4-(3-Hydroxypropyl)morpholine|CS-W002821
      4441-30-9

    References

    • Tammara; Narurkar; Crider; Khan Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 5 p. 644 - 648
  • Route3
    • Methyl 3-morpholinopropionate|CS-0204262
      33611-43-7
    • ~57%
    • In-stock
      4-(3-Hydroxypropyl)morpholine|CS-W002821
      4441-30-9

    References

    • Le Sann, Christine; Huddleston, Jonathan; Mann, John Tetrahedron, 2007 , vol. 63, # 52 p. 12903 - 12911

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3267
Class : 8
Packing Group : Ⅱ
Hazard Statements : H227-H314-H361
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.7
  • LogP   -0.299
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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