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CS-W001157 4
Total: USD 88.00

O-Isopropylhydroxylamine hydrochloride

  • CAS No. 4490-81-7

  • Cat. No. CS-W008733
  • Purity≥97%
  • MDL No.MFCD00231457

*For research and further manufacturing use only, not for direct human use.

O-Isopropylhydroxylamine hydrochloride|CS-W008733

Structure of 4490-81-7

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General Information

  • CAS No. 4490-81-7
  • Cat. No. CS-W008733
  • Purity ≥97%
  • MDL No. MFCD00231457
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₁₀ClNO
  • Molecular Weight 111.57
  • Synonym(s) Hydroxylamine, O-(1-methylethyl)-, hydrochloride
  • SMILES CC(ON)C.[H]Cl

Description

O-Isopropylhydroxylamine hydrochloride is a bench-stable, moisture-tolerant reagent featuring a primary hydroxylamine functionality. This compound enables direct N–O bond formation in amine derivatization and serves as a selective precursor for oxime synthesis under mild conditions.

Application

O-Isopropylhydroxylamine hydrochloride serves as a reliable reagent for the synthesis of oximes and related nitrogen-containing heterocycles. Its bench-stable, crystalline form facilitates handling and purification, while the isopropyl group enhances solubility in organic media. It functions effectively in nucleophilic substitution reactions and enables selective N–O bond formation under mild conditions, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • 2-Isopropoxyisoindoline-1,3-dione|CS-0574844
      51951-27-0
    • ~87%
    • In-stock
      O-Isopropylhydroxylamine hydrochloride|CS-W008733
      4490-81-7

    References

    • Ishikawa; Kamiyama; Matsunaga; Tawada; Iizawa; Okonogi; Miyake Journal of Antibiotics, 2000 , vol. 53, # 10 p. 1071 - 1085
  • Route2
    • null|null
      18498-62-9
    • ~87%
    • In-stock
      O-Isopropylhydroxylamine hydrochloride|CS-W008733
      4490-81-7

    References

    • Khomutov, Maxim A.; Mandal, Swati; Weisell, Janne; Saxena, Neiha; Simonian, Alina R.; Vepsalainen, Jouko; Madhubala, Rentala; Kochetkov, Sergey N. Amino Acids, 2010 , vol. 38, # 2 p. 509 - 517
  • Route3
    • null|null
      3532-27-2
    • ~53%
    • In-stock
      O-Isopropylhydroxylamine hydrochloride|CS-W008733
      4490-81-7

    References

    • Singha, A. S.; Misra, B. N. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 4 p. 361 - 363

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.7069
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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