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CS-W001157 4
Total: USD 88.00

1-(2-Fluorophenyl)ethanol

  • CAS No. 445-26-1

  • Cat. No. CS-0154084
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluorophenyl)ethanol|CS-0154084

Structure of 445-26-1

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General Information

  • CAS No. 445-26-1
  • Cat. No. CS-0154084
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉FO
  • Molecular Weight 140.15
  • Synonym(s) 2-Fluorophenylmethylcarbinol
  • SMILES CC(C1=CC=CC=C1F)O

Description

1-(2-Fluorophenyl)ethanol features a fluorinated aromatic ring coupled to a chiral alcohol side chain, offering enhanced metabolic stability and favorable lipophilicity for medicinal chemistry applications. This bench-stable intermediate integrates readily into bioactive scaffolds through standard functionalization protocols.

Application

1-(2-Fluorophenyl)ethanol serves as a versatile chiral building block in medicinal chemistry, enabling access to bioactive scaffolds through standard functional group interconversions. Its bench-stable nature and compatibility with diverse transformations—such as oxidation, halogenation, and coupling reactions—facilitate efficient synthesis of fluorinated aryl-containing compounds. The molecule functions as a key intermediate in the construction of heterocyclic systems and API precursors requiring ortho-fluorinated aromatic motifs.

Synthesis

  • Route1

    References

    • Mao, Jincheng; Wan, Boshun; Wu, Fan; Lu, Shiwei Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7341 - 7344
  • Route2
    • null|null
      766-49-4
    • ~88%
    • In-stock
      1-(2-Fluorophenyl)ethanol|CS-0154084
      445-26-1

    References

    • Li, Le; Herzon, Seth B. Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17376 - 17379,4 Title/Abstract Full Text Show Details Li, Le; Herzon, Seth B. Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17376 - 17379
  • Route3

    References

    • McEwen, John; Yates, Keith Journal of the American Chemical Society, 1987 , vol. 109, # 19 p. 5800 - 5808

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.879
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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