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CS-W001157 4
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tert-Butyl (chloromethyl) succinate

  • CAS No. 432037-43-9

  • Cat. No. CS-0197232
  • Molecule weight222.67
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (chloromethyl) succinate|CS-0197232

Structure of 432037-43-9

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General Information

  • CAS No. 432037-43-9
  • Cat. No. CS-0197232
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₅ClO₄
  • Molecular Weight 222.67
  • Synonym(s) Tert-Butyl Chloromethylsuccinate
  • SMILES CC(C)(C)OC(=O)CCC(=O)OCCl

Description

tert-Butyl (chloromethyl) succinate features a reactive chloromethyl group flanked by a succinate ester and sterically hindered tert-butyl moiety, enabling selective alkylation under mild conditions. This combination delivers robust stability during handling while facilitating efficient conjugation in synthetic workflows.

Application

tert-Butyl (chloromethyl) succinate serves as a versatile bifunctional synthon, enabling efficient installation of both ester and chloromethyl handles in one molecule. The chloromethyl group facilitates alkylation reactions under mild conditions, while the tert-butyl ester provides orthogonal protection compatible with standard deprotection protocols. Its bench-stable nature and ease of purification make it ideal for multi-step synthesis of complex scaffolds, including heterocyclic systems and peptide analogs.

Synthesis

  • Route1
    • null|null
      49715-04-0
    • In-stock
      4-tert-Butoxy-4-oxobutanoic acid|CS-W008838
      15026-17-2
    • ~%
    • In-stock
      tert-Butyl (chloromethyl) succinate|CS-0197232
      432037-43-9

    References

    • WO2004/89925 A1, ; Page 86-88 ; WO 2004/089925 A1
  • Route2

    References

    • US2002/165201 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331-H341
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.8478
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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