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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethoxy)phenylacetic acid

  • CAS No. 4315-07-5

  • Cat. No. CS-W002285
  • Molecule weight220.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethoxy)phenylacetic acid|CS-W002285

Structure of 4315-07-5

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General Information

  • CAS No. 4315-07-5
  • Cat. No. CS-W002285
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₃
  • Molecular Weight 220.15
  • Synonym(s) 2-[4-(TRIFLUOROMETHOXY)PHENYL]ACETIC ACID
  • SMILES OC(=O)Cc1ccc(cc1)OC(F)(F)F

Description

4-(Trifluoromethoxy)phenylacetic acid features a trifluoromethoxy group that imparts strong electron-withdrawing character and enhanced metabolic stability. This arylacetic acid integrates readily into bioactive scaffolds, offering improved lipophilicity and resistance to oxidative degradation in pharmaceutical development workflows.

Application

4-(Trifluoromethoxy)phenylacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard amide and ester formation. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates straightforward derivatization and purification. The compound exhibits good bench stability and functional group tolerance, making it well-suited for use in high-throughput screening campaigns and process-scale synthesis.

Synthesis

  • Route1
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      870637-76-6
    • ~%
    • In-stock
      4-(Trifluoromethoxy)phenylacetic acid|CS-W002285
      4315-07-5

    References

    • Journal of Medicinal Chemistry, , vol. 14, p. 921 - 925
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 14, p. 921 - 925
  • Route3
    • (4-(Trifluoromethoxy)phenyl)methanol|CS-W010710
      1736-74-9
    • ~%
    • In-stock
      4-(Trifluoromethoxy)phenylacetic acid|CS-W002285
      4315-07-5

    References

    • J. Gen. Chem. USSR (Engl. Transl.), , vol. 35, p. 1628 - 1636,1631 - 1637

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.2123
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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