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Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

  • CAS No. 1206550-93-7

  • Cat. No. CS-0151600
  • Molecule weight248.20
  • Purity≥97%
  • MDL No.MFCD12964233

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate|CS-0151600

Structure of 1206550-93-7

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General Information

  • CAS No. 1206550-93-7
  • Cat. No. CS-0151600
  • Purity ≥97%
  • MDL No. MFCD12964233
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁F₃O₃
  • Molecular Weight 248.20
  • Synonym(s) Ethyl 2-(4-(trifluoromethoxy)
  • SMILES CCOC(=O)CC1=CC=C(C=C1)OC(F)(F)F

Description

Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate features a trifluoromethoxy-substituted phenyl ring conjugated to an acetic acid ester, delivering enhanced electron-withdrawing character and improved metabolic stability. This moiety integrates readily into pharmaceutical intermediates requiring lipophilic, fluorinated aromatic components. The ethyl ester group enables straightforward functionalization under standard conditions.

Application

Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling efficient access to biologically relevant arylacetic acid derivatives. The trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the ester functionality allows for straightforward hydrolysis or further functionalization. This compound exhibits excellent bench stability, tolerates a range of reaction conditions, and facilitates coupling reactions in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   2.6908
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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