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Structure of 43141-66-8
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1-Chloro-4-(difluoromethyl)benzene features a para-substituted difluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability. This aryl halide integrates readily into cross-coupling reactions, serving as a key building block for fluorinated aromatic scaffolds in medicinal chemistry and materials science.
1-Chloro-4-(difluoromethyl)benzene serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into aromatic scaffolds. The chloro substituent facilitates palladium-catalyzed cross-coupling reactions, while the difluoromethyl moiety imparts enhanced metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for constructing bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: