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CS-W001157 4
Total: USD 88.00

2,2-Difluoro-1-phenylethanone

  • CAS No. 395-01-7

  • Cat. No. CS-0095863
  • Purity≥97%
  • MDL No.MFCD06246879

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoro-1-phenylethanone|CS-0095863

Structure of 395-01-7

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General Information

  • CAS No. 395-01-7
  • Cat. No. CS-0095863
  • Purity ≥97%
  • MDL No. MFCD06246879
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O
  • Molecular Weight 156.13
  • Synonym(s) 2,2-Difluoroacetophenone
  • SMILES FC(F)C(C1=CC=CC=C1)=O

Description

TAMRA-PEG4-Alkyne is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm. The alkyne group enables Click Chemistry with azide compounds.

Application

2,2-Difluoro-1-phenylethanone serves as a valuable electrophilic synthon in fluorinated aromatic synthesis, enabling direct introduction of the –CF₂H group into complex molecular architectures. Its bench-stable nature and compatibility with nucleophilic substitution reactions facilitate efficient access to fluorinated ketones and heterocyclic scaffolds relevant to medicinal chemistry. Functions as a key building block for trifluoromethylated motifs and exhibits predictable reactivity in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      359-12-6
    • null|null
      71-43-2
    • ~90%
    • In-stock
      2,2-Difluoro-1-phenylethanone|CS-0095863
      395-01-7

    References

    • Tetrahedron Letters, , vol. 52, # 40 p. 5170 - 5172
  • Route2
    • 2,2-Dichloro-1-phenylethan-1-one|CS-0323833
      2648-61-5
    • ~27%
    • In-stock
      2,2-Difluoro-1-phenylethanone|CS-0095863
      395-01-7

    References

    • Journal of the American Chemical Society, , vol. 108, # 24 p. 7739 - 7744
  • Route3
    • (R)-2,2-Difluoro-1-phenylethan-1-ol|CS-0638427
      82255-42-3
    • ~90%
    • In-stock
      2,2-Difluoro-1-phenylethanone|CS-0095863
      395-01-7

    References

    • Journal of Fluorine Chemistry, , vol. 137, p. 99 - 104

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319
Precautionary Statements : P210-P264-P280-P302+P352-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.1344
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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