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CS-W001157 4
Total: USD 88.00

5-Amino-1-benzofuran-2-carboxylic acid

  • CAS No. 42933-44-8

  • Cat. No. CS-M1933
  • Purity≥96%
  • MDL No.MFCD11505019

*For research and further manufacturing use only, not for direct human use.

5-Amino-1-benzofuran-2-carboxylic acid|CS-M1933

Structure of 42933-44-8

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General Information

  • CAS No. 42933-44-8
  • Cat. No. CS-M1933
  • Purity ≥96%
  • MDL No. MFCD11505019
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇NO₃
  • Molecular Weight 177.16
  • Synonym(s) Vilazodone Intermediate 1
  • SMILES NC1=CC=C2C(C=C(C(O)=O)O2)=C1

Description

5-Amino-1-benzofuran-2-carboxylic acid integrates a polar amino group and a carboxylic acid moiety within a fused benzofuran scaffold, enabling direct functionalization in medicinal chemistry. This electron-rich heterocycle supports efficient coupling reactions under mild conditions, facilitating the synthesis of bioactive compounds.

Application

5-Amino-1-benzofuran-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling and functionalization protocols. The ortho-amino and carboxylic acid groups provide complementary reactivity for peptide bond formation, amidation, and transition-metal-catalyzed transformations. Bench-stable and readily purified by recrystallization, it functions as a key scaffold for developing kinase inhibitors and other pharmaceutical candidates through established synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.46
  • LogP   1.7132
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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