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CS-W001157 4
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Ethyl 5-aminobenzofuran-2-carboxylate

  • CAS No. 174775-48-5

  • Cat. No. CS-M1412
  • Purity≥98%
  • MDL No.MFCD08275091

*For research and further manufacturing use only, not for direct human use.

Ethyl 5-aminobenzofuran-2-carboxylate|CS-M1412

Structure of 174775-48-5

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General Information

  • CAS No. 174775-48-5
  • Cat. No. CS-M1412
  • Purity ≥98%
  • MDL No. MFCD08275091
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO₃
  • Molecular Weight 205.21
  • Synonym(s) Vilazodone Intermediate 5
  • SMILES NC1=CC=C2OC(C(OCC)=O)=CC2=C1

Description

Ethyl 5-aminobenzofuran-2-carboxylate features a fused benzofuran scaffold with a strategically positioned amino group, enabling direct incorporation into bioactive heterocycles. This electron-rich derivative supports efficient derivatization in synthetic medicinal chemistry workflows under standard conditions.

Application

Ethyl 5-aminobenzofuran-2-carboxylate serves as a versatile building block in medicinal chemistry, enabling direct access to functionalized benzofuran scaffolds. The amino group facilitates downstream derivatization via coupling reactions, while the ester moiety supports selective transformations under standard conditions. Its stability and compatibility with diverse reaction environments make it a practical choice for constructing heterocyclic intermediates in API development.

Synthesis

  • Route1

    References

    • ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur Patent: WO2013/153492 A2, 2013 ; Location in patent: Page/Page column 23 ;
  • Route2

    References

    • WO2013/153492 A2, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.46
  • LogP   2.1917
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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