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Structure of 428452-49-7
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3-Amino-2,2-difluoropropanoic acid features a trifluoromethyl-like electronic profile with enhanced stability due to the geminal difluoro substitution. This bench-stable amino acid analog integrates readily into peptide synthesis workflows, offering improved metabolic resistance and controlled polarity for applications in medicinal chemistry and probe development.
3-Amino-2,2-difluoropropanoic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated amino acid derivatives with enhanced metabolic stability. Its difluoromethyl group imparts favorable lipophilicity and resistance to oxidative metabolism, while the α-amino and carboxylic acid functionalities support straightforward peptide coupling and derivatization. The compound exhibits good bench stability and is amenable to standard purification methods, facilitating integration into multi-step synthetic sequences for targeted bioactive molecule development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: