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CS-W001157 4
Total: USD 88.00

2,2-Difluoro-3-hydroxypropylamine

  • CAS No. 155310-11-5

  • Cat. No. CS-B1180
  • Purity≥95%
  • MDL No.MFCD19207959

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoro-3-hydroxypropylamine|CS-B1180

Structure of 155310-11-5

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General Information

  • CAS No. 155310-11-5
  • Cat. No. CS-B1180
  • Purity ≥95%
  • MDL No. MFCD19207959
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇F₂NO
  • Molecular Weight 111.09
  • Synonym(s) 3-Amino-2,2-difluoropropan-1-ol
  • SMILES OCC(F)(F)CN

Description

2,2-Difluoro-3-hydroxypropylamine features a difluoromethyl group flanking a hydroxyl-bearing carbon, delivering enhanced metabolic stability and polarity. This configuration supports targeted bioconjugation and facilitates incorporation into peptide scaffolds where solubility and resistance to enzymatic degradation are critical.

Application

2,2-Difluoro-3-hydroxypropylamine serves as a versatile building block for fluorinated bioactive molecules, enabling efficient incorporation of difluoromethylene and hydroxyl functionalities. Its stability under standard synthetic conditions facilitates use in amide coupling, nucleophilic substitution, and heterocycle formation. The molecule functions as a key intermediate in the synthesis of fluorinated amino alcohols and peptidomimetics, offering favorable handling properties and compatibility with common protecting group strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅱ
Hazard Statements : H227-H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.4273
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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