Lot numbers can be found on the outside label of a product:
4-Aminonicotinaldehyde
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CAS No. 42373-30-8
- Cat. No. CS-W008204
- Purity≥97%
- MDL No.MFCD04038972
*For research and further manufacturing use only, not for direct human use.
Structure of 42373-30-8
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General Information
- CAS No. 42373-30-8
- Cat. No. CS-W008204
- Purity ≥97%
- MDL No. MFCD04038972
- Storage -20°C, protect from light, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₆N₂O
- Molecular Weight 122.12
- Synonym(s) 4-aminopyridine-3-carbaldehyde
- SMILES NC1=C(C=O)C=NC=C1
Description
4-Aminonicotinaldehyde features a pyridine ring bearing both aldehyde and primary amine functionalities at para positions, enabling dual reactivity in synthetic transformations. This electron-rich scaffold integrates readily into bioactive molecule design, offering enhanced solubility and stability under standard bench conditions for medicinal chemistry applications.
Application
4-Aminonicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyridine-based heterocycles and bioactive scaffolds. Its ortho-aldehyde and primary amine functionalities offer complementary reactivity for coupling reactions, Ugi-type condensations, and Schiff base formation. The compound exhibits bench stability and facilitates straightforward purification, making it well-suited for iterative library synthesis and process-scale applications.
Synthesis
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Route1
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In-stock
86847-71-4 - ~87%
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In-stock
42373-30-8
References
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Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert B.; Dinges, Jurgen; Hutchins, Charles W.; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L. Patent: US2003/199511 A1, 2003 ; Location in patent: Page/Page column 24 ;
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Route2
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266353-32-6 - ~59%
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In-stock
42373-30-8
References
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Andreani, Aldo; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Pietra, Claudio; Villetti, Gino European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 77 - 82
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Route3
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In-stock
116026-93-8 - ~92%
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In-stock
42373-30-8
References
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Chan, Laval; Jin, Haolun; Stefanac, Tomislav; Lavallee, Jean-Francois; Falardeau, Guy; Wang, Wei; Bedard, Jean; May, Suzanne; Yuen, Leonard Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3023 - 3025
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H317-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.98
- LogP 0.4763
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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