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CS-W001157 4
Total: USD 88.00

1-(1,3-Thiazol-2-yl)piperazine

  • CAS No. 42270-37-1

  • Cat. No. CS-0122173
  • Purity≥97%
  • MDL No.MFCD00778419

*For research and further manufacturing use only, not for direct human use.

1-(1,3-Thiazol-2-yl)piperazine|CS-0122173

Structure of 42270-37-1

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General Information

  • CAS No. 42270-37-1
  • Cat. No. CS-0122173
  • Purity ≥97%
  • MDL No. MFCD00778419
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁N₃S
  • Molecular Weight 169.25
  • Synonym(s) 2-(Piperazin-1-yl)thiazole
  • SMILES N1(C2=NC=CS2)CCNCC1

Description

1-(1,3-Thiazol-2-yl)piperazine features a thiazole ring fused to a piperazine scaffold, delivering enhanced electron density and metabolic stability. This hybrid structure enables robust coordination in metal complexes and facilitates integration into bioactive molecules. The compound serves as a key building block in medicinal chemistry, particularly for targeting G-protein-coupled receptors and kinase pathways.

Application

1-(1,3-Thiazol-2-yl)piperazine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through straightforward functionalization. Its thiazole moiety imparts enhanced metabolic stability and favorable binding interactions, while the piperazine ring offers multiple sites for derivatization. The compound exhibits excellent bench stability, solubility in common organic solvents, and compatibility with standard coupling reactions, facilitating rapid exploration of structure–activity relationships in drug discovery programs.

Synthesis

  • Route1
    • null|null
      110-85-0
    • In-stock
      2-Bromothiazole|CS-W001223
      3034-53-5
    • ~91%
    • In-stock
      1-(1,3-Thiazol-2-yl)piperazine|CS-0122173
      42270-37-1

    References

    • GRUENENTHAL GmbH Patent: US2010/152158 A1, 2010 ; Location in patent: Page/Page column 29 ; US 20100152158 A1
  • Route2
    • null|null
      110-85-0
    • In-stock
      2-Chlorothiazole|CS-D1169
      3034-52-4
    • ~%
    • In-stock
      1-(1,3-Thiazol-2-yl)piperazine|CS-0122173
      42270-37-1
    • null|null
      131136-87-3

    References

    • Verma, Sanjeev K.; Acharya; Kaushik Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1324 - 1327
  • Route3
    • null|null
      110-85-0
    • In-stock
      2-Chlorothiazole|CS-D1169
      3034-52-4
    • ~%
    • In-stock
      1-(1,3-Thiazol-2-yl)piperazine|CS-0122173
      42270-37-1

    References

    • Howard et al. Journal of Organic Chemistry, 1953 , vol. 18, p. 1484,1487

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.16
  • LogP   0.5527
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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