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CS-W001157 4
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2-(Piperazin-1-yl)thiazole hydrochloride

  • CAS No. 209733-13-1

  • Cat. No. CS-0188231
  • Purity≥98%
  • MDL No.MFCD08752687

*For research and further manufacturing use only, not for direct human use.

2-(Piperazin-1-yl)thiazole hydrochloride|CS-0188231

Structure of 209733-13-1

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General Information

  • CAS No. 209733-13-1
  • Cat. No. CS-0188231
  • Purity ≥98%
  • MDL No. MFCD08752687
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂ClN₃S
  • Molecular Weight 205.71
  • Synonym(s) 2-(1-piperazinyl)thiazole hydrochloride
  • SMILES N1(C2=NC=CS2)CCNCC1.Cl

Description

This piperazinylthiazole derivative features a hydrochloride salt form that enhances solubility and stability in aqueous media. The electron-rich piperazine ring enables efficient coordination in metal-ligand systems, while the thiazole core provides a rigid, planar scaffold suitable for pharmaceutical scaffolding. This compound integrates readily into bioactive molecules requiring polar heterocyclic motifs with tunable basicity.

Application

2-(Piperazin-1-yl)thiazole hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds. Its piperazine moiety offers enhanced solubility and hydrogen-bonding capacity, while the hydrochloride salt ensures improved crystallinity and bench stability. The compound functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive molecules, exhibiting robust compatibility with standard coupling and functionalization reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   28.16
  • LogP   0.9745
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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