Lot numbers can be found on the outside label of a product:
2-Chloro-8-nitroquinoline
-
CAS No. 4225-86-9
- Cat. No. CS-0155824
- Purity≥97%
- MDL No.MFCD00160589
*For research and further manufacturing use only, not for direct human use.
Structure of 4225-86-9
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 4225-86-9
- Cat. No. CS-0155824
- Purity ≥97%
- MDL No. MFCD00160589
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₅ClN₂O₂
- Molecular Weight 208.60
- Synonym(s) 2-Chloro-8-nitro-quinoline
- SMILES C1=CC2=C(C(=C1)[N+](=O)[O-])N=C(C=C2)Cl
Description
2-Chloro-8-nitroquinoline is a nitrogen-containing heterocyclic compound featuring a chlorine substituent at the 2-position and a nitro group at the 8-position. This electron-deficient quinoline scaffold enables direct functionalization in cross-coupling reactions and serves as a key building block for advanced pharmaceutical intermediates and fluorescent probes.
Application
2-Chloro-8-nitroquinoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its electron-deficient quinoline core exhibits enhanced reactivity at the C2 position, while the nitro group provides a handle for reduction and subsequent cyclization. The compound demonstrates excellent bench stability and compatibility with common protecting groups, facilitating modular synthesis of complex heterocyclic scaffolds.
Synthesis
-
Route1
-
In-stock
612-62-4 - ~63%
-
In-stock
4225-86-9
References
-
MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge Patent: WO2010/24980 A1, 2010 ; Location in patent: Page/Page column 93; 94 ;
-
-
References
-
Paloque, Lucie; Verhaeghe, Pierre; Casanova, Magali; Castera-Ducros, Caroline; Dumetre, Aurelien; Mbatchi, Litaty; Hutter, Sebastien; Kraiem-M'Rabet, Manel; Laget, Michele; Remusat, Vincent; Rault, Sylvain; Rathelot, Pascal; Azas, Nadine; Vanelle, Patrice European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 75 - 86
-
-
Route3
-
14753-18-5 - ~%
-
In-stock
4225-86-9
References
-
Ochiai et al. Yakugaku Zasshi, 1943 , vol. 63, p. 280 Chem.Abstr., 1951 , p. 5152
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 56.03
- LogP 2.7964
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 2-Chloro-8-nitroquinoline sigma2-Chloro-8-nitroquinoline manufacturer2-Chloro-8-nitroquinoline price2-Chloro-8-nitroquinoline structure2-Chloro-8-nitroquinoline SDSbuy 2-Chloro-8-nitroquinoline2-Chloro-8-nitroquinoline supplier2-Chloro-8-nitroquinoline uses2-Chloro-8-nitroquinoline molecular weightprice of 2-Chloro-8-nitroquinoline2-Chloro-8-nitroquinoline chemical name formula of 2-Chloro-8-nitroquinoline