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CS-W001157 4
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Hexahydro-1H-pyrrolizine-7a-carboxylic acid

  • CAS No. 412283-63-7

  • Cat. No. CS-0006055
  • Purity≥98%
  • MDL No.MFCD11045065

*For research and further manufacturing use only, not for direct human use.

Hexahydro-1H-pyrrolizine-7a-carboxylic acid|CS-0006055

Structure of 412283-63-7

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General Information

  • CAS No. 412283-63-7
  • Cat. No. CS-0006055
  • Purity ≥98%
  • MDL No. MFCD11045065
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃NO₂
  • Molecular Weight 155.19
  • Synonym(s) Tetrahydro-pyrrolizine-7a-carboxylic acid
  • SMILES O=C(C12CCCN1CCC2)O

Description

Hexahydro-1H-pyrrolizine-7a-carboxylic acid features a saturated pyrrolizidine core with a carboxylic acid at the 7a-position, offering a rigid, electron-rich scaffold ideal for bioactive molecule design. This bench-stable derivative enables direct incorporation into peptide mimetics and pharmaceutical intermediates without protective group manipulation.

Application

Hexahydro-1H-pyrrolizine-7a-carboxylic acid serves as a versatile scaffold for constructing nitrogen-containing heterocycles and bioactive molecules. Its carboxylic acid functionality enables direct derivatization via amide, ester, or salt formation, while the saturated pyrrolizidine core offers stability and compatibility with standard synthetic protocols. Functions as a key building block in medicinal chemistry campaigns targeting CNS-active compounds and enzyme inhibitors.

Synthesis

  • Route1
    • null|null
      78449-71-5
    • ~%
    • In-stock
      Hexahydro-1H-pyrrolizine-7a-carboxylic acid|CS-0006055
      412283-63-7

    References

    • Suzuki, Tomoo; Usui, Toshinao; Oka, Mitsuru; Suzuki, Tsunemasa; Kataoka, Tadashi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1265 - 1273
  • Route2
    • Hexahydro-1H-pyrrolizine-7a-carbonitrile|CS-0081725
      68295-48-7
    • ~%
    • In-stock
      Hexahydro-1H-pyrrolizine-7a-carboxylic acid|CS-0006055
      412283-63-7

    References

    • Suzuki, Tomoo; Usui, Toshinao; Oka, Mitsuru; Suzuki, Tsunemasa; Kataoka, Tadashi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1265 - 1273

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   0.6994
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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