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CS-W001157 4
Total: USD 88.00

7-Bromo-2-methylquinazolin-4(3H)-one

  • CAS No. 403850-89-5

  • Cat. No. CS-W022529
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-2-methylquinazolin-4(3H)-one|CS-W022529

Structure of 403850-89-5

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General Information

  • CAS No. 403850-89-5
  • Cat. No. CS-W022529
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrN₂O
  • Molecular Weight 239.07
  • Synonym(s) quinazolin-​
  • SMILES O=C1NC(C)=NC2=C1C=CC(Br)=C2

Description

7-Bromo-2-methylquinazolin-4(3H)-one features a brominated quinazolinone core with a methyl group at the 2-position, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into kinase inhibitor libraries and serves as a key intermediate in medicinal chemistry campaigns targeting ATP-binding sites.

Application

7-Bromo-2-methylquinazolin-4(3H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via palladium-catalyzed cross-coupling. The quinazolinone core provides a rigid, planar scaffold with favorable pharmacokinetic properties, while the 2-methyl group enhances metabolic stability. Bench-stable and amenable to standard purification methods, it facilitates efficient synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   1.99402
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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