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CS-W001157 4
Total: USD 88.00

2-Methylquinazolin-4-ol

  • CAS No. 1769-24-0

  • Cat. No. CS-0043891
  • Purity≥97%
  • MDL No.MFCD05270928

*For research and further manufacturing use only, not for direct human use.

2-Methylquinazolin-4-ol|CS-0043891

Structure of 1769-24-0

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General Information

  • CAS No. 1769-24-0
  • Cat. No. CS-0043891
  • Purity ≥97%
  • MDL No. MFCD05270928
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) None
  • SMILES O=C1NC(C)=NC2=C1C=CC=C2

Description

2-Methylquinazolin-4-ol delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry applications. The fused ring system combines enhanced metabolic stability with favorable solubility profiles, enabling direct integration into kinase inhibitor scaffolds and other bioactive molecules under standard conditions.

Application

2-Methylquinazolin-4-ol serves as a versatile heterocyclic scaffold for medicinal chemistry and materials science applications. Its core structure enables straightforward derivatization at the 2-methyl and 4-hydroxyl positions, facilitating access to diverse quinazoline-based libraries. The compound exhibits good bench stability and tolerates common functional groups, making it well-suited for modular synthesis workflows. It functions as a key building block in the development of kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1
    • 2-Acetamidobenzamide|CS-0323481
      33809-77-7
    • ~86%
    • In-stock
      2-Methylquinazolin-4-ol|CS-0043891
      1769-24-0

    References

    • Ramana; Sundaram; Eswara Yuvaraj; Ganesh Babu Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 8 p. 905 - 908
  • Route2
    • null|null
      124-42-5
    • In-stock
      2-Bromobenzoic acid|CS-W018527
      88-65-3
    • ~87%
    • In-stock
      2-Methylquinazolin-4-ol|CS-0043891
      1769-24-0

    References

    • Yu, Lin; Wang, Min; Li, Pinhua; Wang, Lei Applied Organometallic Chemistry, 2012 , vol. 26, # 11 p. 576 - 582,7
  • Route3
    • In-stock
      o-Iodobenzoic acid|CS-D0909
      88-67-5
    • null|null
      124-42-5
    • ~97%
    • In-stock
      2-Methylquinazolin-4-ol|CS-0043891
      1769-24-0

    References

    • Yu, Lin; Wang, Min; Li, Pinhua; Wang, Lei Applied Organometallic Chemistry, 2012 , vol. 26, # 11 p. 576 - 582,7

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   1.23152
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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