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Structure of 403850-89-5
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7-Bromo-2-methylquinazolin-4(3H)-one features a brominated quinazolinone core with a methyl group at the 2-position, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into kinase inhibitor libraries and serves as a key intermediate in medicinal chemistry campaigns targeting ATP-binding sites.
7-Bromo-2-methylquinazolin-4(3H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via palladium-catalyzed cross-coupling. The quinazolinone core provides a rigid, planar scaffold with favorable pharmacokinetic properties, while the 2-methyl group enhances metabolic stability. Bench-stable and amenable to standard purification methods, it facilitates efficient synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: