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CS-W001157 4
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2-Aminothiazole-5-carboxylic acid

  • CAS No. 40283-46-3

  • Cat. No. CS-W003268
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Aminothiazole-5-carboxylic acid|CS-W003268

Structure of 40283-46-3

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General Information

  • CAS No. 40283-46-3
  • Cat. No. CS-W003268
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄N₂O₂S
  • Molecular Weight 144.15
  • Synonym(s) 5-Thiazolecarboxylic acid, 2-amino-
  • SMILES O=C(C1=CN=C(N)S1)O

Description

2-Aminothiazole-5-carboxylic acid features a fused thiazole ring bearing both amino and carboxylic acid functionalities, enabling direct incorporation into heterocyclic scaffolds. The electron-rich nitrogen atoms facilitate metal coordination and hydrogen bonding, while the carboxylic acid group supports derivatization via amide or ester formation. This dual functionality enables rapid access to bioactive compounds in medicinal chemistry and materials science applications.

Application

2-Aminothiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through standard coupling and cyclization protocols. Its dual functionality—amine and carboxylic acid—facilitates orthogonal derivatization, while the thiazole core imparts metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and is compatible with common reaction conditions, simplifying purification and integration into multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P363-P501

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   0.4235
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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