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CS-W001157 4
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(2-Formyl-5-methoxyphenyl)boronic acid

  • CAS No. 40138-18-9

  • Cat. No. CS-0113149
  • Purity≥96%
  • MDL No.MFCD03001335

*For research and further manufacturing use only, not for direct human use.

(2-Formyl-5-methoxyphenyl)boronic acid|CS-0113149

Structure of 40138-18-9

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General Information

  • CAS No. 40138-18-9
  • Cat. No. CS-0113149
  • Purity ≥96%
  • MDL No. MFCD03001335
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BO₄
  • Molecular Weight 179.97
  • Synonym(s) 5-Methoxy-2-formylphenylboronic acid
  • SMILES COC(C=C1B(O)O)=CC=C1C=O

Description

This boronic acid features a formyl group ortho to the boronate, enabling direct functionalization in Suzuki-Miyaura couplings. The methoxy substituent enhances solubility and stabilizes the boronate under standard conditions. This combination facilitates efficient cross-coupling with aryl halides, delivering complex phenolic architectures with minimal purification.

Application

(2-Formyl-5-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl architectures. The ortho-formyl group allows for subsequent derivatization via condensation or cyclization, while the methoxy substituent enhances solubility and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis of heterocyclic scaffolds and functionalized aryl targets.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   -0.8125
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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