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CS-W001157 4
Total: USD 88.00

3-Phenylpiperidine

  • CAS No. 3973-62-4

  • Cat. No. CS-W009367
  • Purity≥98%
  • MDL No.MFCD00804860

*For research and further manufacturing use only, not for direct human use.

3-Phenylpiperidine|CS-W009367

Structure of 3973-62-4

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General Information

  • CAS No. 3973-62-4
  • Cat. No. CS-W009367
  • Purity ≥98%
  • MDL No. MFCD00804860
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅N
  • Molecular Weight 161.25
  • Synonym(s) (3S)-3-cyclohexylpiperidinium
  • SMILES C1(C2=CC=CC=C2)CNCCC1

Description

3-Phenylpiperidine delivers a rigid, electron-rich scaffold ideal for medicinal chemistry applications. This aromatic piperidine integrates seamlessly into bioactive molecules, offering enhanced metabolic stability and favorable pharmacokinetic profiles in CNS-targeted drug discovery.

Application

3-Phenylpiperidine serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive molecules through standard functionalization at the piperidine nitrogen and aromatic ring. Its structural rigidity and favorable pharmacophoric profile support diverse applications in CNS-targeted drug discovery. The compound exhibits bench stability and compatibility with common coupling and reduction protocols, facilitating efficient synthesis and purification in multi-step routes.

Synthesis

  • Route1

    References

    • Ablordeppey, Seth Y; Fischer, James B; Law; Glennon, Richard A Bioorganic and medicinal chemistry, 2002 , vol. 10, # 8 p. 2759 - 2765
  • Route2
    • 1-Methyl-3-phenylpiperidine|CS-0569383
      19509-11-6
    • ~%
    • In-stock
      3-Phenylpiperidine|CS-W009367
      3973-62-4

    References

    • Takemiya, Akihiro; Hartwig, John F. Journal of the American Chemical Society, 2006 , vol. 128, # 18 p. 6042 - 6043
  • Route3
    • In-stock
      3-Phenylpyridine|CS-W016252
      1008-88-4
    • null|null
      7732-18-5
    • ~%
    • In-stock
      3-Phenylpiperidine|CS-W009367
      3973-62-4

    References

    • Abbott Laboratories Patent: US5631401 A1, 1997 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.1536
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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